3-Amino-2,6-piperidinedione → HCID 86709856, compound

HRID 2277122Notes

Reaction equation

HRID 2277122 reaction equation
[CH3:1][O:2][C:3]1[C:4]([N+:15]([O-:17])=[O:16])=[C:5]([C:12]([OH:14])=O)[C:6](=[CH:10][CH:11]=1)[C:7]([OH:9])=O.[NH2:18][CH:19]1[CH2:24][CH2:23][C:22](=[O:25])[NH:21][C:20]1=[O:26]>>[O:26]=[C:20]1[CH:19]([N:18]2[C:12](=[O:14])[C:5]3[C:6](=[CH:10][CH:11]=[C:3]([O:2][CH3:1])[C:4]=3[N+:15]([O-:17])=[O:16])[C:7]2=[O:9])[CH2:24][CH2:23][C:22](=[O:25])[NH:21]1

Participants

3

Reactant 2

HCID 1345083-Amino-2,6-piperidinedioneHCID 22663212HCID 22663212, compound

Product 1

HCID 86709856HCID 86709856, compound

Procedure

reacting 4-methoxy-3-nitro-phthalic acid with 3-aminopiperidine-2,6-dione, in one embodiment, in the presence of a coupling reagent, to form 2-(2,6-dioxopiperidin-3-yl)-5-methoxy-4-nitroisoindoline-1,3-dione;

Sources & evidence

ORD record
ord-9183a223d1d8479293d8e7399c06901c
Source dataset
uspto-grants-2015_09
Patent number
US09133161B2

Reaction notes

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