3-Amino-2,6-piperidinedione → HCID 86709858, compound

HRID 2277124Notes

Reaction equation

HRID 2277124 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:15]([OH:17])=O)[C:6]([C:12]([OH:14])=O)=[C:7]([C:9]([OH:11])=[O:10])[CH:8]=1.[NH2:18][CH:19]1[CH2:24][CH2:23][C:22](=[O:25])[NH:21][C:20]1=[O:26]>>[O:26]=[C:20]1[CH:19]([N:18]2[C:12](=[O:14])[C:6]3[C:7]([C:9]([OH:11])=[O:10])=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=3[C:15]2=[O:17])[CH2:24][CH2:23][C:22](=[O:25])[NH:21]1

Participants

3

Reactant 2

HCID 1345083-Amino-2,6-piperidinedioneHCID 85984432HCID 85984432, compound

Product 1

HCID 86709858HCID 86709858, compound

Procedure

reacting 5-methoxy-benzene-1,2,3-tricarboxylic acid with 3-aminopiperidine-2,6-dione, in one embodiment, in the presence of a coupling reagent, to form 2-(2,6-dioxo-piperidin-3-yl)-6-methoxy-1,3-dioxo-2,3-dihydro-1H-isoindole-4-carboxylic acid;

Sources & evidence

ORD record
ord-6d6db66fe3b149fe8c554be6e0091ef0
Source dataset
uspto-grants-2015_09
Patent number
US09133161B2

Reaction notes

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