Urea → HCID 57755858, compound

Participants

Reaction Steps

The product from Step (b) (0.100 g, 0.398 mmol, 1.00 equiv), 4-fluorobenzaldehyde (0.0430 mL, 0.398 mmol, 1.00 equiv), urea (36 mg, 0.60 mmol, 1.0 equiv), and ytterbium triflate (25 mg, 0.040 mmol, 0.10 equiv) and heated to 80° C. for 5.5 hours. The reaction was cooled to room temperature and water was added. The precipitate was collected by filtration and washed alternately with CH3CN and Et2O, affording 98 mg (62%) of the title compound. MS (ES+) m/e 400 [M+H].

Provenance & Evidence