HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 86731192, compound → HCID 136341404, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 86731192 | HCID 86731192 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 136341404 | HCID 136341404 | 87.9% |
Reaction Steps
A mixture of N-((2S)-1-((2-(4-(benzyloxy)-3-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide (1.22 g), 10% palladium-carbon (containing water (50%), 1.00 g) and THF (20 mL) was stirred at room temperature for 20 min under a hydrogen atmosphere. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure. The obtained solid was washed with diethyl ether to give the title compound (850 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133129B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-3cde705e72d34e7b81cdd1b8f72dcfff |
| Source note | uspto-grants-2015_09 |