Hydrogen chloride-ethyl acetate → HCID 86731204, compound

Participants

Reaction Steps

To tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)phenyl)-1H-benzimidazol-6-yl)oxy)propan-2-yl)carbamate (901 mg) was added 4 M hydrogen chloride/ethyl acetate (10 mL), and the mixture was stirred at room temperature for 20 min, and concentrated. To the residue were added pyridine (10 mL) and acetic anhydride (10 mL), and the mixture was stirred at room temperature for 15 min, and concentrated. The residue was dissolved in methanol (10 mL) and THF (10 mL), and saturated aqueous sodium hydrogen carbonate solution (10 mL) was added thereto, and the mixture was stirred at room temperature for 30 min. The reaction mixture was extracted with ethyl acetate, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (NH, hexane/ethyl acetate) to give the title compound (490 mg).

Provenance & Evidence