Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 86731222 | HCID 86731222 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86731221 | HCID 86731221 | 42.9% |
Reaction Steps
A suspension of tert-butyl ((2S)-1-((4-chloro-5-((4-(cyclopropylmethoxy)-3-fluorobenzoyl)amino)pyridin-2-yl)oxy)propan-2-yl)carbamate (990 mg), potassium carbonate (554 mg) and copper(I) iodide (38.2 mg) in DMF (10 mL) was stirred at 160° C. for 5 hr under microwave irradiation. To the reaction mixture was added water, and the obtained mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and subjected to silica gel column chromatography (NH, ethyl acetate). The solvent was evaporated, and the obtained solid was washed with ethyl acetate/hexane to give the title compound (393 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09133129B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-bd04ce034ed448a18a32328657de3aea |
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| Source note | uspto-grants-2015_09 |
|---|
