Urea → HCID 57755848, compound

Participants

Reaction Steps

The product from Example 139, Step (b) (87.3 mg, 0.348 mmol, 1.00 equiv), 2-naphthaldehyde (54 mg, 0.348 mmol, 1.00 equiv), urea (32 mg, 0.53 mmol, 1.0 equiv), and ytterbium triflate (22 mg, 0.035 mmol, 0.10 equiv) and heated to 80° C. for 2 hours. The reaction was cooled to room temperature and water was added. The precipitate was collected by filtration and washed alternately with CH3CN and Et2O, affording 78 mg (52%) of the title compound. MS (ES+) m/e 432 [M+H].

Provenance & Evidence