HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 4-(Cyclopropylmethoxy)-3-fluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 4-(Cyclopropylmethoxy)-3-fluorobenzoic acid | HCID 28604704 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(Cyclopropylmethoxy)-3-fluorobenzoyl chloride | HCID 86731253 | — |
Reaction Steps
To a solution of 4-(cyclopropylmethoxy)-3-fluorobenzoic acid (1.57 g) in THF (50 mL) were added oxalyl dichloride (0.982 mL) and DMF (2 drops), and the mixture was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure to give 4-(cyclopropylmethoxy)-3-fluorobenzoyl chloride. This compound was used for the next reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133129B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-5d20af099d34407f9ba706d37a4467ca |
| Source note | uspto-grants-2015_09 |