反应详情

5-Nitroindazole (20.0 g, 123 mmol, 1 equiv) was suspended in 500 mL MeOH. The mixture was refluxed and bromine (6.3 mL, 123 mmol, 1 equiv) was added dropwise. The reaction was stirred at reflux for 3 hours, then at room temperature for 2 days. The reaction mixture was filtered and the solid was washed with diisopropyl either to afford 24.9 g (84%) of the title compound as a yellow solid.

1. temperatureThe mixture was refluxed
2. temperatureat reflux for 3 hours
3. filtrationThe reaction mixture was filtered
4. washthe solid was washed with diisopropyl either