Tetrahydrofuran → HCID 86731284, compound

Participants

Reaction Steps

A mixture of 6-(2-azidopropoxy)-2-(4-(cyclopropylmethoxy)-3-fluorophenyl)-4,5,6,7-tetrahydro-1,3-benzoxazole (870 mg), 10% palladium-carbon (containing water (50%), 800 mg) and THF (10 mL) was stirred at room temperature for 10 min. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure. To the obtained residue were added pyridine (10 mL) and acetic anhydride (10 mL), and the mixture was stirred at room temperature for 10 min. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate/methanol) to give the title compound (725 mg).

Provenance & Evidence