Ammonium Chloride → HCID 86731289, compound

Participants

Reaction Steps

To a solution of 2-(3-chloro-4-(cyclopropylmethoxy)phenyl)-4,5,6,7-tetrahydro-1,3-benzoxazol-5-ol (5.63 g) and 4-(chloroacetyl)morpholine (4.58 mL) in THF (50 mL) was added potassium tert-butoxide (3.95 g), and the mixture was stirred for 1 hr under a nitrogen stream. To the reaction mixture was added saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate/methanol) to give the title compound (6.22 g).

Provenance & Evidence