1,1,1-Trifluoro-3-iodopropane → HCID 86731300, compound

HRID 2277229Notes

Reaction equation

HRID 2277229 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][C:11]3[CH:17]=[C:16]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:25])[CH3:24])[CH3:21])[CH:15]=[CH:14][C:12]=3[N:13]=2)[CH:5]=[CH:6][C:7]=1[OH:8].[F:26][C:27]([F:32])([F:31])[CH2:28][CH2:29]I>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][C:11]3[CH:17]=[C:16]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:25])[CH3:24])[CH3:21])[CH:15]=[CH:14][C:12]=3[N:13]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:29][CH2:28][C:27]([F:32])([F:31])[F:26]

Participants

3

Reactant 2

HCID 1561651,1,1-Trifluoro-3-iodopropaneHCID 136341404HCID 136341404, compound

Product 1

HCID 86731300HCID 86731300, compound

Procedure

Using N-((2S)-1-((2-(3-fluoro-4-hydroxyphenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide and 1,1,1-trifluoro-3-iodopropane, and in the same manner as in Example 5, the title compound was obtained.

Sources & evidence

ORD record
ord-7a2533aaeefa4ae6b2c2d5b91b82560a
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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