Azetidine → HCID 86731308, compound

HRID 2277235Notes

Reaction equation

[CH:1]1([CH2:4][O:5][C:6]2[C:11]([F:12])=[CH:10][C:9]([C:13]3[O:14][C:15]4[CH:20]=[C:19]([O:21][CH2:22][C@@H:23]([NH:25][C:26](=O)[O:27]C(C)(C)C)[CH3:24])[N:18]=[CH:17][C:16]=4[N:33]=3)=[CH:8][C:7]=2[F:34])[CH2:3][CH2:2]1.[NH:35]1[CH2:38][CH2:37][CH2:36]1>>[CH:1]1([CH2:4][O:5][C:6]2[C:11]([F:12])=[CH:10][C:9]([C:13]3[O:14][C:15]4[CH:20]=[C:19]([O:21][CH2:22][C@@H:23]([NH:25][C:26]([N:35]5[CH2:38][CH2:37][CH2:36]5)=[O:27])[CH3:24])[N:18]=[CH:17][C:16]=4[N:33]=3)=[CH:8][C:7]=2[F:34])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 10422Azetidine

HCID 86731263HCID 86731263, compound

Product 1

HCID 86731308HCID 86731308, compound

Procedure

Using tert-butyl ((2S)-1-((2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)carbamate and azetidine, and in the same manner as in Example 59, the title compound was obtained.

Sources & evidence

ORD record: ord-d553600dff764dadb992a6a7b57b1204
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09133129B2

Reaction notes

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