Water → HCID 86731312, compound

Participants

Reaction Steps

To a solution of (4-fluoro-5-(methoxymethoxy)pyridin-2-yl)methanol (3.59 g) and triethylamine (8.02 mL) in DMSO (30 mL) was added sulfur trioxide pyridine complex (9.16 g), and the mixture was stirred at room temperature for 30 min. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (2.43 g).

Provenance & Evidence