Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2277244Generated: October 25, 2026

6-Chloronicotinic acid → 6-((2,2-difluorocyclopropyl)methoxy)nicotinic Acid

https://huagongshe.com/reaction/2277244

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Chloronicotinic acidHCID 79222—
Reactant(2,2-Difluorocyclopropyl)methanolHCID 2761401—
Product6-((2,2-difluorocyclopropyl)methoxy)nicotinic AcidHCID 86731318—

Reaction Steps

Using 6-chloronicotinic acid and 2,2-difluorocyclopropanemethanol, and in the same manner as in Step A of Example 40, the title compound was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09133129B2
Source datasetuspto-grants-2015_09
ORD IDord-46b035dab57640e7b6248572d3ecd9de
Source noteuspto-grants-2015_09