HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diketene → n-(3-Methyl-1h-indazol-5-yl)-3-oxobutanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diketene | HCID 12661 | — |
| Reactant | HCID 178434299 | HCID 178434299 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | n-(3-Methyl-1h-indazol-5-yl)-3-oxobutanamide | HCID 178468065 | — |
Reaction Steps
5-Amino-3-methylindazole (300 mg, 2.04 mmol, 1.00 equiv) was dissolved in acetonitrile (4 mL) and diketene (151 uL, 2.04 mmol, 1.00 equiv) was added. The reaction mixture was stirred overnight, and the reaction mixture was purified directly by silica gel chromatography (50→100% EtOAc/hexanes)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560467B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-aeaa3ea0c3524b9e9f36c04bb3d359a4 |
| Source note | uspto-grants-2009_07 |