(1-Fluorocyclopropyl)methanol → N-((2S)-1-((2-(4-((1-fluorocyclopropyl)methoxy)phenyl) [1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

HRID 2277264Notes

Reaction equation

HRID 2277264 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]3[CH:22]=[C:21]([O:23][CH2:24][C@@H:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])[N:20]=[CH:19][C:18]=3[N:31]=2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=CC=C[CH:3]=1.[F:32]C1(CO)CC1>>[F:32][C:2]1([CH2:1][O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[O:16][C:17]4[CH:22]=[C:21]([O:23][CH2:24][C@@H:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])[N:20]=[CH:19][C:18]=4[N:31]=3)=[CH:11][CH:10]=2)[CH2:3][CH2:7]1

Participants

3

Reactant 2

HCID 67149022(1-Fluorocyclopropyl)methanolHCID 86731323N-((2S)-1-((2-(4-(benzyloxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

Product 1

HCID 86731339N-((2S)-1-((2-(4-((1-fluorocyclopropyl)methoxy)phenyl) [1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

Procedure

Using N-((2S)-1-((2-(4-(benzyloxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and (1-fluorocyclopropyl)methanol, and in the same manner as in Step A and Step B of Example 4, the title compound was obtained.

Sources & evidence

ORD record
ord-c8acf01188294406acbc8f977becbbd9
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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