HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2,2-Difluorocyclopropyl)methanol → N-((2S)-1-((2-(4-((2,2-difluorocyclopropyl)methoxy)-3,5-difluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2,2-Difluorocyclopropyl)methanol | HCID 2761401 | — |
| Reactant | N-((2S)-1-((2-(4-(benzyloxy)-3,5-difluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide | HCID 86731341 | — |
| Product | N-((2S)-1-((2-(4-((2,2-difluorocyclopropyl)methoxy)-3,5-difluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide | HCID 86731340 | — |
Reaction Steps
Using N-((2S)-1-((2-(4-(benzyloxy)-3,5-difluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and (2,2-difluorocyclopropyl)methanol, and in the same manner as in Step A and Step B of Example 4, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133129B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-bce37a9cf9084c6e99d2b6abc3469bd2 |
| Source note | uspto-grants-2015_09 |