(1-Fluorocyclopropyl)methanol → N-((2S)-1-((2-(3,5-difluoro-4-((1-fluorocyclopropyl)methoxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

HRID 2277266Notes

Reaction equation

HRID 2277266 reaction equation
[CH2:1]([O:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([C:16]2[O:17][C:18]3[CH:23]=[C:22]([O:24][CH2:25][C@@H:26]([NH:28][C:29](=[O:31])[CH3:30])[CH3:27])[N:21]=[CH:20][C:19]=3[N:32]=2)=[CH:11][C:10]=1[F:33])[C:2]1C=CC=[CH:4][CH:3]=1.[F:34]C1(CO)CC1>>[F:33][C:10]1[CH:11]=[C:12]([C:16]2[O:17][C:18]3[CH:23]=[C:22]([O:24][CH2:25][C@@H:26]([NH:28][C:29](=[O:31])[CH3:30])[CH3:27])[N:21]=[CH:20][C:19]=3[N:32]=2)[CH:13]=[C:14]([F:15])[C:9]=1[O:8][CH2:1][C:2]1([F:34])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 67149022(1-Fluorocyclopropyl)methanolHCID 86731341N-((2S)-1-((2-(4-(benzyloxy)-3,5-difluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

Product 1

HCID 86731342N-((2S)-1-((2-(3,5-difluoro-4-((1-fluorocyclopropyl)methoxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

Procedure

Using N-((2S)-1-((2-(4-(benzyloxy)-3,5-difluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and (1-fluorocyclopropyl)methanol, and in the same manner as in Step A and Step B of Example 4, the title compound was obtained.

Sources & evidence

ORD record
ord-8e483d3838244a3cbcebdf2e3d6f0881
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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