2,2,2-Trifluoroethyl trifluoromethanesulfonate → HCID 86731347, compound

HRID 2277270Notes

Reaction equation

HRID 2277270 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[O:11][C:12]3[CH:18]=[C:17]([O:19][CH2:20][C@@H:21]([NH:23][C:24](=[O:26])[CH3:25])[CH3:22])[CH:16]=[CH:15][C:13]=3[N:14]=2)[CH:5]=[C:6]([F:9])[C:7]=1[OH:8].FC(F)(F)S(O[CH2:33][C:34]([F:37])([F:36])[F:35])(=O)=O>>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[O:11][C:12]3[CH:18]=[C:17]([O:19][CH2:20][C@@H:21]([NH:23][C:24](=[O:26])[CH3:25])[CH3:22])[CH:16]=[CH:15][C:13]=3[N:14]=2)[CH:5]=[C:6]([F:9])[C:7]=1[O:8][CH2:33][C:34]([F:37])([F:36])[F:35]

Participants

3

Reactant 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonateHCID 136341407HCID 136341407, compound

Product 1

HCID 86731347HCID 86731347, compound

Procedure

Using N-((2S)-1-((2-(3,5-difluoro-4-hydroxyphenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide and 2,2,2-trifluoroethyl trifluoromethanesulfonate, and in the same manner as in Example 5, the title compound was obtained.

Sources & evidence

ORD record
ord-a5d3d5222d5d42f2b92272763cef2376
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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