Tetrahydrofuran → HCID 86731351, compound

Participants

Reaction Steps

To a mixture of N-((2S)-1-((2-(3-acetyl-4-ethoxy-5-fluorophenyl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide (660 mg), THF (10 mL) and methanol (5 mL) was added sodium borohydride (60.3 mg), and the mixture was stirred at room temperature for 10 min. To the reaction mixture was added saturated aqueous ammonium chloride solution, and the mixture was diluted with ethyl acetate, and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate-ethyl acetate/methanol) to give the title compound (420 mg).

Provenance & Evidence