HCID 86731356, compound → HCID 86731355, compound

HRID 2277276Notes

Reaction equation

HRID 2277276 reaction equation
C(O[C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]3[CH:22]=[C:21]([O:23][CH2:24][C@@H:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])[N:20]=[CH:19][C:18]=3[N:31]=2)=[CH:11][C:10]=1[O:32][CH3:33])C1C=CC=CC=1.[N+](C1C=CC(S([O:46][CH2:47][C@@H:48]2[CH2:50][C:49]2([F:52])[F:51])(=O)=O)=CC=1)([O-])=O>>[F:52][C:49]1([F:51])[CH2:50][C@H:48]1[CH2:47][O:46][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]3[CH:22]=[C:21]([O:23][CH2:24][C@@H:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])[N:20]=[CH:19][C:18]=3[N:31]=2)=[CH:11][C:10]=1[O:32][CH3:33]

Participants

3

Reactant 2

HCID 86731356HCID 86731356, compoundHCID 86731357HCID 86731357, compound

Product 1

HCID 86731355HCID 86731355, compound

Procedure

Using N-((2S)-1-((2-(4-(benzyloxy)-3-methoxyphenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and ((1S)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate, and in the same manner as in Step D of Example 68, the title compound was obtained.

Sources & evidence

ORD record
ord-ec727dd5a3df4c48976f87e96142fb31
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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