Potassium Carbonate → N-((2S)-1-((2-(5-(((1R)-2,2-difluorocyclopropyl)methoxy)pyridin-2-yl) [1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A suspension of N-((2S)-1-((2-(5-hydroxypyridin-2-yl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide (37.4 mg), ((1R)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate (50.1 mg) and potassium carbonate (31.5 mg) in DMF (5 mL) was stirred at 70° C. for 30 min. The reaction mixture was diluted with ethyl acetate, and washed with saturated brine, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated, and the obtained solid was washed with diethyl ether to give the title m compound (12.4 mg).

Herkunft & Nachweise