2-(Bromomethyl)-1,1-difluorocyclopropane → HCID 86731365, compound

HRID 2277282Notes

Reaction equation

HRID 2277282 reaction equation
[F:1][CH:2]([F:28])[O:3][C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:18]=[C:17]([O:19][CH2:20][C@@H:21]([NH:23][C:24](=[O:26])[CH3:25])[CH3:22])[N:16]=[CH:15][C:14]=3[N:27]=2)[CH:7]=[CH:8][C:9]=1[OH:10].Br[CH2:30][CH:31]1[CH2:33][C:32]1([F:35])[F:34]>>[F:34][C:32]1([F:35])[CH2:33][CH:31]1[CH2:30][O:10][C:9]1[CH:8]=[CH:7][C:6]([C:11]2[O:12][C:13]3[CH:18]=[C:17]([O:19][CH2:20][C@@H:21]([NH:23][C:24](=[O:26])[CH3:25])[CH3:22])[N:16]=[CH:15][C:14]=3[N:27]=2)=[CH:5][C:4]=1[O:3][CH:2]([F:1])[F:28]

Participants

3

Reactant 2

HCID 27614022-(Bromomethyl)-1,1-difluorocyclopropaneHCID 136341409HCID 136341409, compound

Product 1

HCID 86731365HCID 86731365, compound

Procedure

Using N-((2S)-1-((2-(3-(difluoromethoxy)-4-hydroxyphenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and 2-(bromomethyl)-1,1-difluorocyclopropane, and in the same manner as in Example 5, the title compound was obtained.

Sources & evidence

ORD record
ord-a975541f7c044548849bec6fd087db2e
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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