Methylparaben → methyl 4-(((1R)-2,2-difluorocyclopropyl)methoxy)benzoate

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Reaction Steps

Using methyl 4-hydroxybenzoate and ((1R)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate, and in the same manner as in Example 5, the title compound was obtained. 1H NMR (300 MHz, DMSO-d6) δ 1.41-1.61 (1H, m), 1.66-1.84 (1H, m), 2.13-2.38 (1H, m), 3.81 (3H, s), 3.99-4.14 (1H, m), 4.18-4.31 (1H, m), 7.00-7.15 (2H, m), 7.85-7.97 (2H, m).

Provenance & Evidence