HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(((1R)-2,2-difluorocyclopropyl)methoxy)benzoic Acid → 2-(((2S)-2-((tert-butoxycarbonyl)amino)propyl)oxy)-5-((4-(((1R)-2,2-difluorocyclopropyl)methoxy)benzoyl)amino)pyridin-4-yl 4-(((1R)-2,2-difluorocyclopropyl)methoxy)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(((1R)-2,2-difluorocyclopropyl)methoxy)benzoic Acid | HCID 86731370 | — |
| Reactant | HCID 178461779 | HCID 178461779 | — |
| Product | 2-(((2S)-2-((tert-butoxycarbonyl)amino)propyl)oxy)-5-((4-(((1R)-2,2-difluorocyclopropyl)methoxy)benzoyl)amino)pyridin-4-yl 4-(((1R)-2,2-difluorocyclopropyl)methoxy)benzoate | HCID 86731372 | — |
Reaction Steps
Using tert-butyl ((2S)-1-((5-amino-4-hydroxypyridin-2-yl)oxy)propan-2-yl)carbamate and 4-(((1R)-2,2-difluorocyclopropyl)methoxy)benzoic acid, and in the same manner as in Step D of Example 83, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133129B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-555521b6942d4d019ca345ec39ef69e0 |
| Source note | uspto-grants-2015_09 |