HuagongsheHuagongshe Chemistry Print Report · For research reference only
((1R)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate → ethyl 5-(((1R)-2,2-difluorocyclopropyl)methoxy)-3-fluoropyridine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | ((1R)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate | HCID 86731320 | — |
| Reactant | Ethyl 3-fluoro-5-hydroxypicolinate | HCID 86731382 | — |
| Product | ethyl 5-(((1R)-2,2-difluorocyclopropyl)methoxy)-3-fluoropyridine-2-carboxylate | HCID 86731383 | — |
Reaction Steps
Using ethyl 3-fluoro-5-hydroxypyridine-2-carboxylate and ((1R)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate, and in the same manner as in Example 5, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133129B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-1e327da9fda844d3b601a50adca45c0f |
| Source note | uspto-grants-2015_09 |