tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamate → HCID 178461785, compound

HRID 2277312Notes

Reaction equation

HRID 2277312 reaction equation
C([O:8][C:9]1[C:14]([N+:15]([O-])=O)=[CH:13][N:12]=[C:11]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH3:21])[N:10]=1)C1C=CC=CC=1.[Cl:30][C:31]1[C:32]([C:44](O)=[O:45])=[N:33][CH:34]=[C:35]([O:37][CH2:38][C@H:39]2[CH2:41][C:40]2([F:43])[F:42])[CH:36]=1>>[Cl:30][C:31]1[C:32]([C:44]([NH:15][C:14]2[C:9]([OH:8])=[N:10][C:11]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH3:21])=[N:12][CH:13]=2)=[O:45])=[N:33][CH:34]=[C:35]([O:37][CH2:38][C@H:39]2[CH2:41][C:40]2([F:43])[F:42])[CH:36]=1

Participants

3

Reactant 2

HCID 86731375tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamateHCID 867313973-chloro-5-(((1R)-2,2-difluorocyclopropyl)methoxy)pyridine-2-carboxylic acid

Product 1

HCID 178461785HCID 178461785, compound

Procedure

Using tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamate and 3-chloro-5-(((1R)-2,2-difluorocyclopropyl)methoxy)pyridine-2-carboxylic acid, and in the same manner as in Step A of Example 4 and Step D of Example 83, the title compound was obtained.

Sources & evidence

ORD record
ord-5df9881d957b46b2a91a81bdda3997aa
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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