HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethylcyclopropane → N-((2S)-1-((2-(4-(cyclopropylmethoxy)-2-(2,2,2-trifluoroethoxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | N-((2S)-1-((2-(4-(benzyloxy)-2-(2,2,2-trifluoroethoxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide | HCID 86731399 | — |
| Product | N-((2S)-1-((2-(4-(cyclopropylmethoxy)-2-(2,2,2-trifluoroethoxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide | HCID 86731400 | — |
Reaction Steps
Using N-((2S)-1-((2-(4-(benzyloxy)-2-(2,2,2-trifluoroethoxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and (bromomethyl)cyclopropane, and in the same manner as in Step D of Example 68, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133129B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-3602c4a44b7c4f92997cab30ae81a812 |
| Source note | uspto-grants-2015_09 |