HRID2277318

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18757507

4-(Benzyloxy)-3-fluorobenzoic acid

C14H11FO3

结构：C[C@@H](COc1ncc([N+](=O)[O-])c(OCc2ccccc2)n1)NC(=O)OC(C)(C)C

HCID86731375

Carbamic acid, N-[(1S)-1-methyl-2-[[5-nitro-4-(phenylmethoxy)-2-pyrimidinyl]oxy]ethyl]-, 1,1-dimethylethyl ester

C19H24N4O6

PRODUCTS

生成物

结构：C[C@@H](COc1ncc(NC(=O)c2ccc(OCc3ccccc3)c(F)c2)c(O)n1)NC(=O)OC(C)(C)C

HCID178461783

未命名化合物

PROCEDURE

实验过程

Using tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamate and 4-(benzyloxy)-3-fluorobenzoic acid, and in the same manner as in Step A of Example 4, Step D of Example 83 and Step B of Example 123, the title compound was obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bd675b06841c4e638e7f7353c06e68ec
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09133129B2
来源说明: uspto-grants-2015_09

反应 SMILES

C([O:8][C:9]1[C:14]([N+:15]([O-])=O)=[CH:13][N:12]=[C:11]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH3:21])[N:10]=1)C1C=CC=CC=1.[CH2:30]([O:37][C:38]1[CH:46]=[CH:45][C:41]([C:42](O)=[O:43])=[CH:40][C:39]=1[F:47])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[CH2:30]([O:37][C:38]1[CH:46]=[CH:45][C:41]([C:42]([NH:15][C:14]2[C:9]([OH:8])=[N:10][C:11]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH3:21])=[N:12][CH:13]=2)=[O:43])=[CH:40][C:39]=1[F:47])[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1