((1R)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate → HCID 86731405, compound

HRID 2277319Notes

Reaction equation

HRID 2277319 reaction equation
C(O[C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]3[N:18]=[C:19]([O:24][CH2:25][C@@H:26]([NH:28][C:29](=[O:35])[O:30][C:31]([CH3:34])([CH3:33])[CH3:32])[CH3:27])[N:20]=[CH:21][C:22]=3[N:23]=2)=[CH:11][C:10]=1[F:36])C1C=CC=CC=1.[N+](C1C=CC(S([O:49][CH2:50][C@H:51]2[CH2:53][C:52]2([F:55])[F:54])(=O)=O)=CC=1)([O-])=O>>[F:55][C:52]1([F:54])[CH2:53][C@@H:51]1[CH2:50][O:49][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]3[N:18]=[C:19]([O:24][CH2:25][C@@H:26]([NH:28][C:29](=[O:35])[O:30][C:31]([CH3:33])([CH3:32])[CH3:34])[CH3:27])[N:20]=[CH:21][C:22]=3[N:23]=2)=[CH:11][C:10]=1[F:36]

Participants

3

Reactant 2

HCID 86731320((1R)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonateHCID 86731406HCID 86731406, compound

Product 1

HCID 86731405HCID 86731405, compound

Procedure

Using tert-butyl ((2S)-1-((2-(4-(benzyloxy)-3-fluorophenyl)[1,3]oxazolo[5,4-d]pyrimidin-5-yl)oxy)propan-2-yl)carbamate and ((1R)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate, and in the same manner as in Step A of Example 4 and Example 5, the title compound was obtained.

Sources & evidence

ORD record
ord-dc790a3b850b49209728865fb17ffed9
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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