HRID2277319

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：O=[N+]([O-])c1ccc(S(=O)(=O)OC[C@H]2CC2(F)F)cc1

HCID86731320

未命名化合物

反应SMILES：C[C@@H](COc1ncc2nc(-c3ccc(OCc4ccccc4)c(F)c3)oc2n1)NC(=O)OC(C)(C)C

HCID86731406

未命名化合物

PRODUCTS

产物

反应SMILES：C[C@@H](COc1ncc2nc(-c3ccc(OC[C@H]4CC4(F)F)c(F)c3)oc2n1)NC(=O)OC(C)(C)C

HCID86731405

未命名化合物

PROCEDURE

实验过程

Using tert-butyl ((2S)-1-((2-(4-(benzyloxy)-3-fluorophenyl)[1,3]oxazolo[5,4-d]pyrimidin-5-yl)oxy)propan-2-yl)carbamate and ((1R)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate, and in the same manner as in Step A of Example 4 and Example 5, the title compound was obtained.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-dc790a3b850b49209728865fb17ffed9
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US09133129B2
来源说明: uspto-grants-2015_09

反应SMILES

C(O[C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]3[N:18]=[C:19]([O:24][CH2:25][C@@H:26]([NH:28][C:29](=[O:35])[O:30][C:31]([CH3:34])([CH3:33])[CH3:32])[CH3:27])[N:20]=[CH:21][C:22]=3[N:23]=2)=[CH:11][C:10]=1[F:36])C1C=CC=CC=1.[N+](C1C=CC(S([O:49][CH2:50][C@H:51]2[CH2:53][C:52]2([F:55])[F:54])(=O)=O)=CC=1)([O-])=O>>[F:55][C:52]1([F:54])[CH2:53][C@@H:51]1[CH2:50][O:49][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]3[N:18]=[C:19]([O:24][CH2:25][C@@H:26]([NH:28][C:29](=[O:35])[O:30][C:31]([CH3:33])([CH3:32])[CH3:34])[CH3:27])[N:20]=[CH:21][C:22]=3[N:23]=2)=[CH:11][C:10]=1[F:36]