1132843-09-4 → HCID 86731407, compound

HRID 2277320Notes

Reaction equation

HRID 2277320 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][C:11]3[CH:16]=[C:15]([O:17][CH2:18][C@@H:19]([NH:21][C:22](=[O:24])[CH3:23])[CH3:20])[N:14]=[CH:13][C:12]=3[N:25]=2)[CH:5]=[CH:6][C:7]=1[OH:8].CS(O[CH2:31][CH:32]1[CH2:35][C:34]([F:37])([F:36])[CH2:33]1)(=O)=O>>[F:36][C:34]1([F:37])[CH2:35][CH:32]([CH2:31][O:8][C:7]2[CH:6]=[CH:5][C:4]([C:9]3[O:10][C:11]4[CH:16]=[C:15]([O:17][CH2:18][C@@H:19]([NH:21][C:22](=[O:24])[CH3:23])[CH3:20])[N:14]=[CH:13][C:12]=4[N:25]=3)=[CH:3][C:2]=2[F:1])[CH2:33]1

Participants

3

Reactant 2

HCID 582234121132843-09-4HCID 136341410HCID 136341410, compound

Product 1

HCID 86731407HCID 86731407, compound

Procedure

Using N-((2S)-1-((2-(3-fluoro-4-hydroxyphenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and (3,3-difluorocyclobutyl)methyl methanesulfonate, and in the same manner as in Example 5, the title compound was obtained.

Sources & evidence

ORD record
ord-5c46a6d1a74e463fbcc13ff431d24ce1
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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