2-Chloro-5-(cyclopropylmethoxy)pyrimidine → HCID 86731416, compound

HRID 2277327Notes

Reaction equation

HRID 2277327 reaction equation
Cl[C:2]1[N:7]=[CH:6][C:5]([O:8][CH2:9][CH:10]2[CH2:12][CH2:11]2)=[CH:4][N:3]=1.[O:13]1[C:21]2[CH:20]=[C:19]([O:22][CH2:23][C@@H:24]([NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30])[CH3:25])[N:18]=[CH:17][C:16]=2[N:15]=[CH:14]1>>[CH:10]1([CH2:9][O:8][C:5]2[CH:4]=[N:3][C:2]([C:14]3[O:13][C:21]4[CH:20]=[C:19]([O:22][CH2:23][C@@H:24]([NH:26][C:27](=[O:33])[O:28][C:29]([CH3:31])([CH3:30])[CH3:32])[CH3:25])[N:18]=[CH:17][C:16]=4[N:15]=3)=[N:7][CH:6]=2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 534406182-Chloro-5-(cyclopropylmethoxy)pyrimidineHCID 86731417HCID 86731417, compound

Product 1

HCID 86731416HCID 86731416, compound

Procedure

Using 2-chloro-5-(cyclopropylmethoxy)pyrimidine and tert-butyl ((2S)-1-([1,3]oxazolo[4,5-c]pyridin-6-yloxy)propan-2-yl)carbamate, and in the same manner as in Step B of Example 22, the title compound was obtained.

Sources & evidence

ORD record
ord-66a412fb43ba4ed588591285eae06009
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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