3-Hydroxybutyl 4-methylbenzenesulfonate → N-((2S)-1-((2-(3-fluoro-4-(3-hydroxybutoxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

HRID 2277329Notes

Reaction equation

HRID 2277329 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][C:11]3[CH:16]=[C:15]([O:17][CH2:18][C@@H:19]([NH:21][C:22](=[O:24])[CH3:23])[CH3:20])[N:14]=[CH:13][C:12]=3[N:25]=2)[CH:5]=[CH:6][C:7]=1[OH:8].CC1C=CC(S(O[CH2:37][CH2:38][CH:39]([OH:41])[CH3:40])(=O)=O)=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][C:11]3[CH:16]=[C:15]([O:17][CH2:18][C@@H:19]([NH:21][C:22](=[O:24])[CH3:23])[CH3:20])[N:14]=[CH:13][C:12]=3[N:25]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:37][CH2:38][CH:39]([OH:41])[CH3:40]

Participants

3

Reactant 2

HCID 132043233-Hydroxybutyl 4-methylbenzenesulfonateHCID 136341410HCID 136341410, compound

Product 1

HCID 86731420N-((2S)-1-((2-(3-fluoro-4-(3-hydroxybutoxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

Procedure

Using N-((2S)-1-((2-(3-fluoro-4-hydroxyphenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and 3-hydroxybutyl 4-methylbenzenesulfonate, and in the same manner as in Example 5, the title compound was obtained.

Sources & evidence

ORD record
ord-8f848fadbd264b2fa4d8e591ffebb450
Source dataset
uspto-grants-2015_09
Patent number
US09133129B2

Reaction notes

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