Maleic Acid → N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide maleate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 5 by using N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (1000 mg, 1.80 mmol) in DCM/MeOH (45 mL, v/v=1:2), and a solution of maleic acid (220 mg, 1.90 mmol) in MeOH (2 mL). The title compound was obtained as a white solid (973 mg, 80.5%).

Provenance & Evidence