Benzenesulfonic Acid → N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide benzenesulfonate

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example of 5 by using N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (650 mg, 1.17 mmol) in DCM/MeOH (30 mL, v/v=1:2), and a solution of benzenesulfonic acid (194 mg, 1.22 mmol) in MeOH (1.5 mL). The title compound was obtained as a white solid (595 mg, 71.5%).

Provenance & Evidence