1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 60172731, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 11 by using (S)-1-((4-(4-aminophenoxy)quinolin-7-yl)oxy)propan-2-ol (3.24 g, 10.5 mmol), 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid (2.55 g, 11.0 mmol), EDCI (2.4 g, 12.5 mmol) and HOAT (0.28 g, 2.1 mmol) in DCM (21 mL). The crude product was purified by a column chromatography on silica gel (EtOAc) to afford the title compound as a yellow solid (1.82 g, 33.2%).

Provenance & Evidence