Hydrochloric Acid → HCID 178486758, compound

Participants

Reaction Steps

To a solution of 1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone (29.00 g, 108 mmol) in DME (700 mL) was added sodium methoxide (46.70 g, 864 mmol) in portions. The reaction was stirred at room temperature for 30 minutes, then ethyl formate was added (64 mL, 648 mmol), and continued to stir for 8 hours. The mixture was diluted with H2O (500 mL) and neutralized with 1 N HCl. The resulted solid was collected through filtration, washed with water and dried in vacuo overnight to afford the title compound as a yellow solid (15.9 g, 53%).

Provenance & Evidence