Ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate → Ethyl 4-amino-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylate

Participants

Reaction Steps

3.89 g (16.26 mmol) of 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylic acid ethyl ester is dissolved in 50 ml of THF and mixed with a spatula tip full of Raney nickel. The reaction mixture is hydrogenated with hydrogen in a hydrogenating apparatus at room temperature. The catalyst is filtered off, and the filtrate is concentrated by evaporation in a vacuum. The evaporation residue is reused immediately for the next reaction.

Provenance & Evidence