p-(Trifluoromethoxy)phenyl isocyanate → 4-[({[4-(Trifluoromethoxy)phenyl]amino}carbonyl)amino]-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylic acid ethyl ester

Participants

Reaction Steps

7.49 g (35.8 mmol) of 4-amino-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylic acid ethyl ester is mixed in 18 ml of THF under argon with 6 g (35.8 mmol) of 4-(trifluoromethoxy)phenylisocyanate and stirred for 4 hours at room temperature. The reaction mixture is concentrated by evaporation in a vacuum, and the product that crystallizes out in this case is stirred in 40 ml of ethyl acetate and suctioned off.

Provenance & Evidence