Water → 4-[({[4-(Trifluoromethoxy)phenyl]amino}carbonyl)amino]-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylic acid

Participants

Reaction Steps

10.6 g (28.1 mmol) of 4-[({[4-(trifluoromethoxy)phenyl]amino}-carbonyl)amino]-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylic acid ethyl ester is suspended in 158 ml of ethanol. While being cooled with ice, 16.4 ml of water and 6 ml (112 mmol) of 50% aqueous sodium hydroxide solution are added. The reaction mixture is stirred for 1 hour at room temperature and then concentrated by evaporation in a vacuum. The residue is taken up in 100 ml of isopropanol and mixed with 100 ml of 1N hydrochloric acid while being cooled with ice. The crystals are suctioned off and dried in a vacuum at 40° C.

Provenance & Evidence