Hydrochloric Acid → 1-(5-Methyl-2-pyridinyl)piperazine

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Reaction Steps

3.47 g (12.5 mmol) of 1-(tert-butyloxycarbonyl)-4-(5-methylpyridin-2-yl)piperazine is dissolved in 10 ml of dioxane and mixed with 31 ml (125 mmol) of hydrogen chloride in dioxane (4 mol). It is allowed to stir for 2 hours at room temperature. Then, it is concentrated by evaporation, the residue is alkalized with 1 M sodium hydroxide solution, and it is extracted several times with dichloromethane. The combined organic phases are dried on sodium sulfate, concentrated by evaporation, and dried in a vacuum.

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