Potassium Carbonate → HCID 70914076, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 2-[(2-Cyano-acetyl)-(2-ethoxy-ethyl)-amino]-benzoic acid ethyl ester (1 eq, 0.200 g, 0.66 mmole) in dimethylformamide (25 mL) was added potassium carbonate (1.5 eq, 0.136 g , 0.99 mmole) the resulting mixture was heated to 80° C. for 4 hours. Reaction mixture was diluted with 1N HCl aq (25 mL) and extracted with ethyl acetate (25 mL×3). Combined organic phase was washed consecutively with water, brine before, drying over sodium sulfate. Organic phase was evaporated and the residue was purified by flash chromatography to afford 1-(2-Ethoxy-ethyl)-4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carbonitrile as a pale yellow solid (0.161 g, 95%, LCMS calc M+H 259, obs M+H 259).

Provenance & Evidence