4-Chloro-3-fluorophenylboronic Acid → HCID 90407227, compound

HRID 2277475Notes

Reaction equation

HRID 2277475 reaction equation
Br[C:2]1[N:6]([CH2:7][CH2:8][CH3:9])[CH:5]=[N:4][C:3]=1[C:10]1[CH:15]=[C:14]([C:16]#[N:17])[CH:13]=[CH:12][N:11]=1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][C:20]=1[F:28]>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:2]2[N:6]([CH2:7][CH2:8][CH3:9])[CH:5]=[N:4][C:3]=2[C:10]2[CH:15]=[C:14]([C:16]#[N:17])[CH:13]=[CH:12][N:11]=2)=[CH:21][C:20]=1[F:28]

Participants

3

Reactant 2

HCID 27786564-Chloro-3-fluorophenylboronic AcidHCID 90407434HCID 90407434, compound

Product 1

HCID 90407227HCID 90407227, compound

Procedure

The title compound was prepared from 2-(5-bromo-1-propyl-1H-imidazol-4-yl)pyridine-4-carbonitrile and 4-chloro3-fluorophenylboronic acid according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C18H14ClFN4, 342. Found, 341, 343.

Sources & evidence

ORD record
ord-b1679343b4d24b9192a19c2c58a7cc5e
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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