4-Chloro-3-fluorophenylboronic Acid → HCID 90407302, compound

HRID 2277477Notes

Reaction equation

HRID 2277477 reaction equation
Br[C:2]1[N:6]([CH2:7][CH2:8][CH2:9][O:10][CH3:11])[CH:5]=[N:4][C:3]=1[C:12]1[CH:17]=[C:16]([C:18]#[N:19])[CH:15]=[CH:14][N:13]=1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][C:22]=1[F:30]>>[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([C:2]2[N:6]([CH2:7][CH2:8][CH2:9][O:10][CH3:11])[CH:5]=[N:4][C:3]=2[C:12]2[CH:17]=[C:16]([C:18]#[N:19])[CH:15]=[CH:14][N:13]=2)=[CH:23][C:22]=1[F:30]

Participants

3

Reactant 2

HCID 27786564-Chloro-3-fluorophenylboronic AcidHCID 90407491HCID 90407491, compound

Product 1

HCID 90407302HCID 90407302, compound

Procedure

The title compound was prepared from 2-[5-bromo-1-(3-methoxypropyl)-1H-imidazol-4-yl]pyridine-4-carbonitrile and 4-chloro3-fluorophenylboronic acid according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C19H16ClFN4O, 372. Found, 371, 373.

Sources & evidence

ORD record
ord-7d6eda35119f41dda8f269973f59438f
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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