4-Chloro-3-fluorophenylboronic Acid → HCID 90407045, compound

HRID 2277479Notes

Reaction equation

HRID 2277479 reaction equation
Br[C:2]1[N:6]([CH2:7][CH2:8][O:9][CH3:10])[CH:5]=[N:4][C:3]=1[C:11]1[CH:16]=[C:15]([C:17]#[N:18])[CH:14]=[CH:13][N:12]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][C:21]=1[F:29]>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:2]2[N:6]([CH2:7][CH2:8][O:9][CH3:10])[CH:5]=[N:4][C:3]=2[C:11]2[CH:16]=[C:15]([C:17]#[N:18])[CH:14]=[CH:13][N:12]=2)=[CH:22][C:21]=1[F:29]

Participants

3

Reactant 2

HCID 27786564-Chloro-3-fluorophenylboronic AcidHCID 90407915HCID 90407915, compound

Product 1

HCID 90407045HCID 90407045, compound

Procedure

The title compound was prepared from 2-[5-bromo-1-(2-methoxyethyl)-1H-imidazol-4-yl]pyridine-4-carbonitrile and 4-chloro-3-fluorophenylboronic acid according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C18H14ClFN4O, 358. Found, 357, 359.

Sources & evidence

ORD record
ord-f4910a08c3d74c21ba9bbaea891f6a01
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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