4-Chloro-3-fluorophenylboronic Acid → HCID 178510204, compound

HRID 2277481Notes

Reaction equation

HRID 2277481 reaction equation
Br[C:2]1[NH:6][CH:5]=[N:4][C:3]=1[C:7]1[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=1.[Cl:15][C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][C:17]=1[F:25]>>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:2]2[NH:6][CH:5]=[N:4][C:3]=2[C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)=[CH:18][C:17]=1[F:25]

Participants

3

Reactant 2

HCID 27786564-Chloro-3-fluorophenylboronic AcidHCID 90407399HCID 90407399, compound

Product 1

HCID 178510204HCID 178510204, compound

Procedure

The title compound was prepared from 2-(5-bromo-1H-imidazol-4-yl)pyridine-4-carbonitrile and 4-chloro-3-fluorophenylboronic acid according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C15H8ClFN4, 300. Found, 299, 301.

Sources & evidence

ORD record
ord-5270dbfced574a9ca3da58862d136c5e
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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