3-Bromo-pyrrolidine-1-carboxylic acid tert-butyl ester → HCID 90407703, compound

HRID 2277493Notes

Reaction equation

HRID 2277493 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][N:7]=2)[N:3]=[CH:2]1.[C:14]([N:21]1[CH2:25][CH2:24][CH:23](Br)[CH2:22]1)([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15]>>[C:12]([C:10]1[CH:9]=[CH:8][N:7]=[C:6]([C:4]2[N:3]=[CH:2][N:1]([CH:24]3[CH2:23][CH2:22][N:21]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:25]3)[CH:5]=2)[CH:11]=1)#[N:13]

Participants

3

Reactant 2

HCID 426142173-Bromo-pyrrolidine-1-carboxylic acid tert-butyl esterHCID 178510201HCID 178510201, compound

Product 1

HCID 90407703HCID 90407703, compound

Procedure

The title compound was prepared from 2-(1H-imidazol-4-yl)pyridine-4-carbonitrile and 1-boc-3-bromopyrrolidine according to the procedure for the preparation of Example 43, part A (heating to 120°). [M+H] Calc'd for C18H21N5O2, 340. Found, 340.

Workup

  1. temperatureA (heating to 120°)

Sources & evidence

ORD record
ord-6c0557ad6a9749a9b4cfc1d766c61250
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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