反应详情

温度

0 °C

To a 0° C. solution of methyl 2-[1-(2-hydroxyethyl)-1H-imidazol-4-yl]pyridine-4-carboxylate (500 mg, 2 mmol) in DCM (10 mL) was added TEA (255 mg, 2.5 mmol) followed by drop-wise addition of a solution of methanesulfonyl chloride (255 mg, 2.22 mmol) in DCM (2 mL). The solution was stirred at 0° C. for 1 hr and then allowed to warm to r.t. where stirring was continued for 1 hr. MeOH (1 mL) was then added and stirring was continued for 30 min. The solution was diluted with DCM (50 mL), washed with water (50 mL), dried (MgSO4), filtered, and concentrated to give the title compound as an oily residue (649 mg).

1. temperatureto warm to r.t. where
2. stirringstirring
3. waitwas continued for 1 hr
4. stirringstirring
5. waitwas continued for 30 min
6. washwashed with water (50 mL)
7. dry with materialdried (MgSO4)
8. filtrationfiltered
9. concentrationconcentrated