[3-(Benzylcarbamoyl)-4-fluorophenyl]boronic acid → HCID 90407830, compound

HRID 2277508Notes

Reaction equation

HRID 2277508 reaction equation
Br[C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=1.[CH2:16]([NH:23][C:24]([C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][C:31]=1[F:32])=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:16]([NH:23][C:24](=[O:25])[C:26]1[CH:27]=[C:28]([C:2]2[N:6]([CH3:7])[CH:5]=[N:4][C:3]=2[C:8]2[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=2)[CH:29]=[CH:30][C:31]=1[F:32])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 44717583[3-(Benzylcarbamoyl)-4-fluorophenyl]boronic acidHCID 904081442-(5-Bromo-1-methylimidazol-4-yl)pyridine-4-carbonitrile

Product 1

HCID 90407830HCID 90407830, compound

Procedure

The title compound was prepared from 2-(5-bromo-1-methyl-1H-imidazol-4-yl)pyridine-4-carbonitrile (PREPARATION 2) and 3-(benzylcarbamoyl)-4-fluorophenyl boronic acid according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C24H18FN5O, 412. Found, 412.

Sources & evidence

ORD record
ord-99ddea58308f49108af8c42bab30b244
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

Loading…